Detailed Drug Information:

DRUG CLASS AND MECHANISM: Guaifenesin is an expectorant, thatis, a medication that promotes elimination of mucus from the lungs. Theexpectorant effects of guaifenesin promote elimination of mucous bythinning the mucous and lubricating the irritated respiratory tract.Guaifenesin is an ingredient in many over-the-counter cough and coldproducts. Guaifenesin was first approved by the FDA in 1952.

PREPARATIONS: Prescription forms include syrup (100 mg per teaspoonful); 200 mg tablets (200 Organidin NR); sustained release 300 mg capsules (Humibid); 600 mg sustainedrelease tablets (Fenesin; Humibid LA). The only non-prescription form is a 600 mg extended release tablet (Mucinex).

STORAGE: Tablets, capsules, and syrup should be stored below 30°C(86°F). Do not refrigerate the liquid.

PRESCRIBED FOR: Guaifenesin is used for the treatment of coughassociated with colds and minor upper respiratory tract infections.

DOSING: Guaifenesin may be taken with or without food. Thesustained release tablets and capsules should be taken whole. They shouldnot be broken or opened.

DRUG INTERACTIONS: There are no known drug interactions withguaifenesin.

PREGNANCY: Although one analysis found a correlation betweenguaifenesin use in the first trimester and an increased risk of hernia inthe fetus, others found no increased risk of fetal malformations. Thus,guaifenesin should be used in pregnancy only if the physician feels thatthe potential benefits outweigh the potential and unknown risks.

NURSING MOTHERS: It is not known if guaifenesin is secreted into breast milk.

SIDE EFFECTS: Side effects of guaifenesin are uncommon. In doseshigher than those typically used, nausea, vomiting, diarrhea, abdominalpain, or drowsiness may occur.